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 Printable version |
Effects of treatments on serum vitamin E levels in lung cancer |
Bulletin du Cancer. Volume 91, Number 10, 779-84, Octobre 2004, Article original
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 Résumé
Article gratuit
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Author(s) : Leïla Trabelsi Alouane , Chekib Ghawar , Fatma Tritar Cherif , Dalenda Belhabib , Mohsen Maalej |
Summary : Previous evidence suggests that malignant tumours cause an decrease in the serum vitamin E level. We followed the serum alpha tocophérol in 55 lung cancer patients. The objective of the study was to evaluate the effects of treatments of lung cancer on serum vitamin E evolution. The vitamin E of patients symptomatically treated decreases from the first month and this decrease is significant (p <\; 0.001) in patients affected by SCLC and in those with NSCLC classified stage III and IV. The reduction of the vitamin E is also noted in the patients treated with chemotherapy (p <\; 0.001). Vitamin E levels improve gradually to reach standard values in the patients who followed a curative radiotherapy or benefited from the surgical ablation of the tumour. At 4 months after the surgical removal of the tumour, there was an increase in serum vitamin E concentrations and reached the normal values. This data indicates that surgical removal of lung cancer increases serum vitamin E concentrations compared to the baseline values possibly reflecting the relief of oxidative stress caused by malignant tumours. |
Keywords : serum vitamin E, lung cancer, radiotherapy, chemotherapy, surgery |
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