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p53 status and response to chemotherapy |
Bulletin du Cancer. Volume 89, Number 12, 1007-10, Décembre 2002, Point sur…
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 Résumé
Article gratuit
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Author(s) : Jean Bénard, Jean-Charles Ahomadégbé |
Summary : Numerous studies deal with "p53 status" in patients' tumors (mutated/wild gene status, protein level and functionality) to predict chemotherapy efficacy. Analyses of various cancers, especially breast cancers, lead to controversy that is apparent due to heterogeneity of their design. Recent data from literature lead now to consider i) the nature of chemotherapeutic agents and the regimen, ii) the cancer tissue type, and iii) the histological response of the primary. Molecular actors of senescence, cytostasis and apoptosis, which are responsible of cytotoxic response of cancer cells, are currently under elucidation. |
Keywords : p53 status, breast cancer, chemotherapy, therapeutic response. |
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