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 Printable version |
Genetic alterations of transcription cofactors in solid tumors |
Bulletin du Cancer. Volume 89, Number 4, 357-64, Avril 2002, Synthèses
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 Résumé
Article gratuit
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Author(s) : Jean-François Rouayrenc, Audrey Castet, Jean-Marc Rey, Jean-Paul Brouillet, Pascal Pujol, Françoise Vignon, Thierry Maudelonde, Vincent Cavaillès |
Summary : Many hormones exert their effects through specific nuclear receptors which belong to a superfamily of ligand-activated transcription factors. These receptors control target gene expression through the recruitment of different cofactors acting as transcription activation or repression mediators, generally as parts of multiprotein complexes. The importance and the role in physiopathology of these different cofactors only begin to be defined. Different types of alterations affecting genes coding nuclear receptor transcription cofactors have indeed been described in cancer. The most important examples are gene amplification that leads to overexpression and gene mutations or translocations introducing qualitative modifications. This paper aims at bringing together the corresponding literature and focuses on gene alterations observed in solid tumors. |
Keywords : cancer, nuclear receptor, transcription cofactor, amplification. |
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