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Invovlement of ephrins and their receptors in oncogenesis

Bulletin du Cancer. Volume 87, Number 7-8, 529-30, Numéro double 7 - 8, Juillet -Août 2000, Point sur…

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Author(s) : Gilles L’Allemain

Summary : Ephrins are membrane-linked ligands with an autocrine and/or immediate paracrine action. Ephrins were previously involved in embryonic neurogenesis, axonal guidance and/or retraction. Here, we will present data of the literature describing their roles in angiogenesis and in tumor progression. The capacity for ephrins to act in opposite directions will be discussed.

Keywords : ephrin, angiogenesis.


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