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Fas, Fas ligand, immune tolerance and cancer: involvement in colon cancer |
Bulletin du Cancer. Volume 85, Number 2, 129-33, Février 1998, Synthèses
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 Résumé
Article gratuit
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Author(s) : Anne Berger, Bernard Piqueras, Franck Pages, Eric Tartour, Paul-Henri Cugnenc, Wolf Herman Fridman |
Summary : Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma. |
Keywords : Fas (CD95), Fas ligand, tumor escape, colonic neoplasms. |
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