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beta-catenin mutations in a common skin cancer : pilomatricoma |
Bulletin du Cancer. Volume 86, Number 9, 725-6, Septembre 1999, Point sur…
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 Résumé
Article gratuit
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Author(s) : Matthieu Durand, Jean-Pierre Molès |
Summary : The normal hair development requires WNT signalling pathways. A constitutive activation of beta-catenin, one of the components of this cascade, induces an abnormal proliferation of hair matrix cells. This activation is observed in a human skin tumours called pilomatricoma. Mutations of the beta-catenin gene are detected in 75% of the tumours analysed. |
Keywords : WNT pathway, beta-catenin, skin cancer. |
