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 Printable version |
When p19ARF meets a partner : a possible « liaison dangereuse » |
Bulletin du Cancer. Volume 85, Number 6, 523, Juin 1998, Point sur…
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 Résumé
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Author(s) : Christian-Jacques Larsen |
Summary : In man, the MTS1 (multiple tumor suppressor 1) locus has been located on chromosome band 9p21 and encodes two unrelated genes, p16 INK4a and p19 ARF that both act, through different mechanisms, as cell proliferation inhibitors. The inhibitory mechanism of p19 ARF has begun to be elucidated by the finding that the protein has the ability to bind the mdm2 oncoprotein. mdm2 is implicated in the degradation of p53 and its functional inactivation. While this result provides an opportunity for understanding the tumor suppression role of p19 ARF, it allows to define a new cell cycle regulatory pathway, the p19 ARF -p53 pathway. In this respect, MTS1 is unique in its ability to control two crucial pathways that regulate the cell cycle. For this reason, it will be crucial to investigate the status of p19 ARF in a variety human tumors. |
Keywords : p19ARF, mdm2. |
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