John Libbey Eurotext

MT Cardio

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Regulatory T cells protect against the development of atherosclerosis Volume 2, issue 6, Novembre-Décembre 2006

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Authors
Centre de recherche cardiovasculaire, Inserm Lariboisière U689, hôpital Lariboisière, 41 bd de la Chapelle, 75475 Paris Cedex 10

Atherosclerosis is an inflammatory disease of the arterial wall where both innate and adaptative Th1-driven immunoinflammatory responses contribute to disease development. Th2-related responses have been shown to be either protective or pathogenic. A novel subset of T cells, called regulatory T cells, has been shown recently to play a critical role in the maintenance of immunological tolerance against self and non-self antigens and prevents the development of autoimmune diseases. Here, we report a novel view of the immunoinflammatory response in atherosclerosis where natural and/or adaptative regulatory T cell responses modulate both Th1 and Th2 pathogenic responses and protect against the development of atherosclerosis.