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Journal de Pharmacie Clinique

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Metastatic non-small-cell lung cancer treatment: which chemotherapy? Volume 26, issue 1, Janvier-Février-Mars 2007

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Authors
Service pharmacie, Hôpital européen Georges Pompidou, HEGP, AP-HP, 20, rue Leblanc, 75015 Paris, Service d’oncologie médicale, Hôpital européen Georges Pompidou, HEGP, AP-HP, 20, rue Leblanc, 75015 Paris

The therapeutic strategy of metastatic non-small-cell lung cancer (NSCLC) has known a qualitative evolution these last ten years. The added value of chemotherapy versus palliative care has been demonstrated by several meta-analyses. New molecules with better efficacy-toxicity ratio (vinorelbine, paclitaxel, docetaxel, gemcitabine, pemetrexed) improved the therapeutic strategy according to the patient performance status. Platinum-based combination remains the standard of care in first line treatment with a median survival of 8 months and a one-year median survival of 35%, while no particular doublet shown its superiority. Currently, a second line treatment is a standard. Regarding targeted therapies, their role in NSCLC are under way.