JLE

Journal de Pharmacie Clinique

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Stability of a codein and codethyline hydrochloride potion by liquid chromatography in real conservation conditions at St Antoine University Hospital in Paris Volume 27, issue 2, avril-mai-juin 2008

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Authors
Service de pharmacie, CHU Saint-Antoine, Paris, Service de pharmacie, Centre hospitalier de Chambéry

Saint-Lazare potion is an antidiarrheal containing two derivatives of morphine: codeine and codethyline hydrochloride at a concentration of 6,52 mg/mL. No marketed product exists with such level of concentration. The potion is prepared by Saint-Antoine University Hospital Pharmacy unit since the early eighties.. As the potion contains narcotics, it must be stored in a strongbox, that is to say protected from light and at rooi temperature. No stability study is available, therefore it is prepared whenever needed, for one patient at a time and never more than a week. The aim of this work is to assess stability of Saint-Lazare potion, in order to be able to prepare it in advance and for a few patients, as an “hospital preparation”. This study has been performed on 26 weeks during summer 2003. Four potions A, B, C and D were prepared and stored either in white glass (A and B), either in amber glass (C and D) at room temperature. Measurement of temperature was performed with a temperature sensor. Every week, 1 mL of each potion was sampled and analyzed by liquid chromatography (LC). The analyzed samples went up to 104. Saint-Lazare potion is stable at a temperature of 25,1 ± 3,0 °C in white or amber glass for at least 26 weeks.