JLE

Journal de Pharmacie Clinique

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Radiosynoviorthesis: an alternative to osmic acid Volume 24, issue 2, avril-mai-juin 2005

Authors
Service de pharmacie clinique et des biomatériaux, Groupe hospitalier Bichat-Claude Bernard, Paris, Service de médecine nucléaire et biophysique, Groupe hospitalier Bichat-Claude Bernard, Paris, Service de rhumatologie, Groupe hospitalier Bichat-Claude Bernard, Paris

Synoviorthesis designs a local treatment by intra-articular injection consisting in destroying synovial membrane. This treatment is indicated in a number of invalidating articular rhumatologic affections when general treatment is in failure. In order to achieve the compromise between efficiency and tolerance, a review of synoviorthesis and their drugs is made. Synoviorthesis were carried out a long time using a preparation made up of an 1% osmic acid solution. With the difficulties of control of raw material, considered in fact as a reagent of laboratory, alternatives were required. The radiopharmaceuticals beta emitters radioisotopes with short period, in colloidal form, offer, for a long time, the effectiveness, safety and tolerance necessary to carry out this substitution.