Journal de Pharmacie Clinique
MENURadiosynoviorthesis: an alternative to osmic acid Volume 24, issue 2, avril-mai-juin 2005
- Key words: synoviorthesis, osmic acid, radioisotope
- Page(s) : 83-9
- Published in: 2005
Synoviorthesis designs a local treatment by intra-articular injection consisting in destroying synovial membrane. This treatment is indicated in a number of invalidating articular rhumatologic affections when general treatment is in failure. In order to achieve the compromise between efficiency and tolerance, a review of synoviorthesis and their drugs is made. Synoviorthesis were carried out a long time using a preparation made up of an 1% osmic acid solution. With the difficulties of control of raw material, considered in fact as a reagent of laboratory, alternatives were required. The radiopharmaceuticals beta emitters radioisotopes with short period, in colloidal form, offer, for a long time, the effectiveness, safety and tolerance necessary to carry out this substitution.