- Author(s): Victor Gueutin, Gilbert Deray, Corinne Isnard-Bagnis, Nicolas Janus
, Service de néphrologie, GHU Pitié-Salpêtrière, Paris, Service ICAR, Service de néphrologie, GHU Pitié-Salpêtrière, Paris
- Key words: physiology, glomerulus, tubule, renal blood flow, tubulo-glomerular feedback
- Page(s) : 209-14
- DOI : 10.1684/jpc.2011.0191
- Published in: 2011
The kidneys are responsible for the urinary excretion of uremic toxins and the regulation of several body systems such as intra and extracellular volume status, acid-base status, calcium and phosphate metabolism or erythropoiesis. They adapt quantitative and qualitative composition of the urine to keep these systems in balance. The flow of plasma is filtered in the range of 120 mL/min, and depends on the systemic and renal hemodynamics which is subject to self-regulation. The original urine will then be modified in successive segments of the nephron. The proximal nephron is to lead the massive reabsorption of water and essential elements such as sodium, bicarbonates, amino acids and glucose. The distal nephron includes the distal convoluted tubule, the connector tube and the collecting duct. Its role is to adapt the quality composition of urine to the needs of the body.