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Journal de Pharmacie Clinique

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Influence of intravenous admixtures on the stability of the new solution of 5-fluorouracil Volume 16, issue 1, Mars 1997

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Authors
Service de pharmacie et de toxicologie, Hôpital intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France.

Our aim was to study the stability of the new solution of 5-fluorouracil (5FU) in admixtures for continuous intravenous infusion sodium chloride 0.9 %, dextrose 5 % and plasmalyte 3G5. 5FU was diluted to 0.5 and 5 g.l­ 1 in polyvinyl chloride minibags. The stability was checked in 3 batches. Admixtures were stored at 4 °C and 25 °C for 13 days. The bags were visually inspected and tested for pH. 5-fluorouracil concentration was tested in each admixtures by high performance liquid chromatography (HPLC) immediately after preparation and at regular intervals during the storage (J0, J3, J6, J9, J13). Results have shown that storage conditions (4 °C or 25 °C), for 13 days did not influence concentration of 5FU.