John Libbey Eurotext

Journal de Pharmacie Clinique

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Fluoxetine and hyponatremia : a case report in elderly Volume 17, issue 3, Septembre 1998

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  • Key words: hyponatremia, fluoxetine, elderly, antidiuretic hormon.
  • Page(s) : 169-74
  • Published in: 1998

The Selective Serotonin Reuptake Inhibitors (SSRIs) present a high therapeutic indice. Nevertheless, the occurrence of hyponatremia induced by SSRIs, in the elderly should require some caution. We report the case of a mild, transient hyponatremia secondary to inappropriate secretion of antidiuretic hormone (SIADH) in a 94-year old woman after five weeks of treatment with fluoxetine, at usual dosage and with a total fluoxetine plasma concentration in therapeutic range. This case is compared with the whole cases reports of hyponatremia associated with fluoxetine published in the literature.