JLE

Journal de Pharmacie Clinique

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Formulation of a lignocaine gel for painful cares Volume 17, issue 2, Juin 1998

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In order to adapt to requirements of Surgical Emergency Service, the Pharmacy of Beaujon Hospital adjusted a manufacturing and control procedure for a lignocaine gel higher concentrated than commercial ones, whose application on painful areas allowes to obtain a fast and effective local anesthesia. Four manufacturing procedures, elaborated according to GMP, have been evaluated to choose the one offering the best feasability in Hospital Pharmacy and at the same time, conforms cleanliness level (evaluated by counting of total germs per gramme of final product) and lignocaine amount (controled by an assay for lignocaine amount by high performance liquid chromatography). The formula containing 20 % lignocaine in starch glycerol without preservative has been choosen, and manufacturing on a preparatory, with clean material. Its bacteriologic and physicochimic stability has been validated for five months.