John Libbey Eurotext

Innovations & Thérapeutiques en Oncologie


Macrophages associated with tumours: new therapeutic targets Volume 4, issue 5-6, September-December 2018


  • Figure 1
1 Centre hospitalier universitaire du Kremlin-Bicêtre
Service de médecine interne
78, rue du Général Leclerc
94270 Le Kremlin-Bicêtre
2 Institut Jules Bordet – ULB
Department of medical oncology
121-125, boulevard de Waterloo
1000 Bruxelles
* Tirés à part
  • Key words: macrophages, tumor microenvironment, immunotherapy
  • DOI : 10.1684/ito.2018.0140
  • Page(s) : 235-9
  • Published in: 2018

Macrophages are versatile immune cells that harbour multiple functions in order to maintain homeostasis. The tumour microenvironment with its metabolites alters the status of macrophages, which then become pro-tumoural and therefore protect cancer cells from being attacked by cytotoxic T cells. Additionally, cancer cells secrete different chemokines that attract immature macrophages, which also have a higher protumoural potential. Recently, many different molecules have been developed to target macrophages, and as a result, these may have the potential to convert protumoural macrophages into antitumoural macrophages. These efforts should result in a better antitumoural response when combined with chemotherapy or immune checkpoint inhibitors.