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Innovations & Thérapeutiques en Oncologie

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Hepatic arterial infusion chemotherapy and colorectal cancer with liver metastases Volume 4, issue 1, January-February 2018

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Authors
1 Centre Hospitalier Lyon-Sud
Service d’hépato-gastroentérologie
69495 Pierre-Bénite
France
2 Hôpital Lyon-Sud Pierre-Bénite
Hospices civils de Lyon
Service de chirurgie digestive et oncologique
Lyon
France
3 Hôpital Lyon-Sud Pierre-Bénite
Hospices civils de Lyon
Service de radiologie digestive
Lyon
France
4 Université Claude Bernard Lyon 1
Lyon
France
* Tirés à part

Predominant liver metastatic disease concerns 30% of colorectal cancers. Systemic chemotherapy (cytotoxic agents and targeted therapies) greatly improved the prognosis of these patients. Hepatic intra-arterial chemotherapy is based on the preferential vasculature of liver metastases by the hepatic artery, which allows lesions to be exposed to a high cytotoxic concentration while limiting systemic toxicity. It has been effective for many years in advanced stages. Evaluation of its place in earlier stages is pending.

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