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MENUPharmacotherapy of behavioral disorders in autism with intellectual deficit. Clinical approach for the prescriber Volume 94, issue 6, Juin-Juillet 2018
- Key words: autism, pervasive developmental disorder, social adjustment, mental retardation, behavioral disorder, neuroleptic, antidepressant, psychotropic, drug therapy
- DOI : 10.1684/ipe.2018.1830
- Page(s) : 485-99
- Published in: 2018
Many publications exist in the field of “autism and psychotropics”, but there remains a great disparity in the objectives, methods, results and risks of adverse effects, which leads to a lack of consensus. However, the high incidence of behavioral disorders in intellectually impaired autistic subjects, who are probably the most complex to approach therapeutically and who are most vulnerable to adverse effects, makes it difficult for clinicians to assess the timing of treatment, medication, the practical efficacy and the safety of the latter. In this article, we describe a method of complex analysis of behavioral problems in these patients (most of whom intervene in an interaction with the context) before proposing a decisional modality of choice, conduct and evaluation of the prescription based on data from the literature, the identification of a therapeutic target and the consideration of the safety profile of the molecule.
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