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Adverse effects of antipsychotics in children and adolescents and their surveillance Volume 94, issue 2, Février 2018

Authors
1 Interne
2 PU-PH
* Correspondance
a Service de médecine psychologique de l’enfant et de l’adolescent, (MPEA1), CHU Montpellier, Hôpital Saint-Éloi, 80 avenue Augustin-Fliche 34295 Montpellier cedex 5, France

In France, in the field of child and adolescent psychiatry, antipsychotics are mainly used to treat severe disruptive symptoms, mainly in non-psychotic disorders. The prescription rates of atypical antipsychotics has risen in US and Europe during the past ten years. In adults, numerous papers have been published focusing on the side-effects of atypical antipsychotics. Furthermore, in France their prescription and monitoring have been the subject of specific recommendations. However, no national prescription guidelines are available for children and adolescents. In the first section, we will detail the main side-effects of atypical antipsychotics in the paediatric population such as metabolic syndrome, hyperprolactinemia, and cardiovascular symptoms. Then, we will briefly describe neurological and behavioural side-effects, as well as leukopenia and hypersalivation. Based on CAMESA (Canadian Alliance for Monitoring Effectiveness and Safety of Antipsychotics in Children) and other studies, we will also provide a guide to prevent and manage the side-effects of antipsychotics.

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