Hépato-Gastro & Oncologie Digestive
MENUFirst line chemotherapy in metastatic colorectal cancer: importance of the tumoral response Volume 18, supplement 1, Mai-Juin 2011
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- Key words: colorectal cancer, metastases, induction chemotherapy, tumoral response, maintenance therapy
- DOI : 10.1684/hpg.2011.0574
- Page(s) : 29-36
- Published in: 2011
The importance of the tumoral response for potentially resectable metastasis undergoing chemotherapy is not controversial. This tumoral response is more and more becoming an up-to-date goal for unresectable metastasis when maintenance therapy or treatment-free periods are considered. An objective response for the majority of patients can hopefully be brought by regimen combining cytotoxic chemotherapy together with targeting-biotherapies, with limited toxicity due to short course chemo-induction. These combining regimens allow the best efficiency of maintenance regimens. An early K-RAS status determination is needed to optimise the response rate when using anti-EGFR in first line metastatic colorectal cancer. Targeted therapies offer a strong rational as maintenance treatments. They are being assessed in several ongoing phase III trials.