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Cribriform-morular variant of papillary thyroid carcinoma associated with familial adenomatous polyposis Volume 25, issue 6, Juin 2018

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Authors
1 Institut Curie,
Service de radiothérapie,
75005 Paris,
France
2 Institut Curie,
Service de pathologie,
75005 Paris,
France
3 Institut Curie,
Service de génétique,
unité de génétique constitutionnelle,
75005 Paris,
France
4 Institut Curie,
Service de génétique,
unité de génétique somatique,
75005 Paris,
France
5 Institut Curie,
Département d’oncologie chirurgicale,
75005 Paris,
France
* Tirés à part

Cribriform-morular variant of papillary thyroid carcinoma is a rare entity, which is frequently associated with familial adenomatous polyposis. The aim of this mini-review is to summarize the available data related to this rare condition and to stress the importance of not ignoring this possible association given the major issues for patients and their relatives. Indeed, the diagnosis of familial adenomatous polyposis should be systematically mentioned in all subjects with cribriform-morular variant of papillary thyroid carcinoma. It may be the first phenotypic manifestation of the disease and the absence of family history does not rule out the diagnosis, particularly because of the relative frequency of neo-mutations of the APC gene. Our review is illustrated by the case of a cervical mass incidentally identified in a 24 years old women affected with APC-associated familial adenomatous polyposis. A total thyroidectomy was performed. The pathological examination of the surgical specimen allowed the diagnosis of multifocal cribriform-morular variant of papillary thyroid carcinoma. Surgery was followed by adjuvant iratherapy and by levothyroxin treatment.

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