Hépato-Gastro & Oncologie Digestive
MENUMetastatic colorectal cancers: A step-up strategy in a palliative setting? Volume 26, issue 1, Janvier 2019
- Key words: colorectal cancer, metastases, chemotherapy
- DOI : 10.1684/hpg.2018.1725
- Page(s) : 59-65
- Published in: 2019
Some patients will not be fit to surgical resection of their colorectal cancer and its metastases, even after an induction chemotherapy, for example if numerous metastases are located in several sites or in almost all hepatic segments. Colorectal cancers usually concern patients more than 65 years old, with co-morbidities especially cardio-vascular ones. The aim of the oncological treatment is then not to achieve a tumor response but the longest survival with the lowest toxicity rate. A step-up strategy allows avoiding the adverse effects during the first line of treatment. In a selected population, convergent results of academic trials showed the absence of deleterious effect in terms of survival with this step-up strategy.
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