Laboratoire signalisation et récepteurs matriciels (SiRMa), UMR CNRS 7369 Matrice extracellulaire et dynamique cellulaire (MEDyC), UFR sciences exactes et naturelles, SFR CAP santé, université de Reims Champagne Ardenne, Reims, France
Laboratoire de biochimie et de biologie moléculaire, UMR CNRS 7369 MEDyC, UFR médecine, SFR CAP santé, Reims, France
The extracellular matrix (ECM) consists of a complex set of macromolecules present in all organs and tissues and forms a three-dimensional network between cells. Considered for a long time as a naïve architectural support for cells, ECM is now regarded as a dynamic structure, finely regulated between neosynthesis and degradation, and essential for functional properties of tissues. Matrix aging corresponds to molecular alterations affecting long half-life proteins such as elastin and collagen, the main ECM components, and leads to an important ECM remodeling. At the vascular level, matrix remodeling plays major role in the development of many age-related diseases such as diabetes, hypertension, aneurysms, atherosclerosis or thrombosis. After a brief presentation of the major components of vascular ECM, this review will address the main vascular alterations occurring during matrix aging and then present an update of the effects of elastin degradation and elastokine production on the development of age-related vascular diseases. New pharmacological approaches targeting ECM to minimize elastin degradation, production of elastokines, and/or their cellular effects, may be promising to prevent age-related vascular diseases.