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The new WHO classification for neoplasia Volume 8, issue 1, Janvier - Février 2002

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Service central « Jacques-Delarue » d'anatomie et de cytologie pathologiques (Pr J. Audouin), Hôtel-Dieu, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04.

The WHO has recently published a new classification for neoplasias arising from hematopoietic and lymphoid tissues. In this short review, the classification and its principles are discussed. The entities described are compared with those of previous classifications such as the up-dated Kiel or the REAL classifications. Lymphomas comprise first lymphoblastic acute leukaemias and/or lymphomas arising from B or T cell precursors, and second lymphomas constituted by mature or peripheral B or T cells. The various entities are classified for prognosis appreciation according to four types of survival curves. Hodgkin's disease, whose B lymphoid cell origin is well demonstrated, can be called lymphoma and is subdivided in two different entities, the lymphocyte rich nodular and the classic one. Neoplasias constituted by histiocytes and dendritic cells and by mast cells are also discussed. This overview completes the review recently done by G. Flandrin in this journal for the classification of myeloid cell neoplastic disorders.