Service d'immuno-hématologie,hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris Cedex 10.
B cell development and differentiation is a long and slow process which
leads to the generation of cells producing and secreting immunoglobulins. A large number of genes are involved in this process. Some of these genes are B cell specific whereas other are shared by T lymphocytes or other cell lineages. Interruptions of key events occurring in this differentiative pathway may result in antibody deficiencies, and cumulative mutations of genes affecting growth and differentiation often lead to B cell malignancies.