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Expression and function of Hox genes in normal and leukemic hematopoiesis Volume 3, issue 2, Mars - Avril 1997

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Hox genes were first recognized for their role in embryonic development and may also play lineage-specific functions in a variety of somatic tissues including the hematopoietic system. The regulated expression of these transcription factors was recently demonstrated both in normal and leukemic human marrow suggesting a role for these genes in normal and neoplastic hematopoiesis. Several studies have shown that Hox proteins are involved in controlling proliferation of primitive bone marrow cells and also in altering differentiation of myeloid as well as lymphoid progenitors.