John Libbey Eurotext

Environnement, Risques & Santé

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Endocrine disruption and human reproduction risk assessment: Today's scientific challenges and the stakes for tomorrow Volume 10, issue 6, Novembre-Décembre 2011

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Ineris Toxicologie expérimentale Parc technologique ALATA BP 2 60550 Verneuil-en-Halatte France, Inserm Unité mixte de recherche (UMR) S-747 45, rue des Saints-Pères 75006 Paris France
  • Key words: endocrine disruptors, risk assessment, technology, toxic actions
  • DOI : 10.1684/ers.2011.0498
  • Page(s) : 454-68
  • Published in: 2011

For many years, the issue of endocrine disruptors (ED) has persisted as an unresolved question for research, the public and regulatory bodies. As the mechanisms of action of ED are progressively elucidated, other issues have arisen, in connection with new challenges. The strategy of evaluation of these substances has been supported: i) by multidisciplinary research intended to characterise the targets and modes of action of ED; ii) by the development of highly specific tools; and iii) by the development of an appropriate regulatory framework. Despite promising technologies, assessment of ED toxicity still has inherent limitations. Thus, researchers seeking to optimise the characterisation of hazards are moving in new directions, with lower doses, mixtures of substances, targeted exposure windows and ever more predictive tools.