Diffusion imaging in human partial epilepsies Volume 20, issue 2, avril-mai-juin 2008


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Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Faculté de Médecine, Université de la Méditerranée, 27, boulevard Jean Moulin, F 13385 Marseille cedex 05, France, Laboratoire de Neurophysiologie et Neuropsychologie, INSERM U751, et Service de Neurophysiologie Clinique, Faculté de Médecine, Université de la Méditerranée, et CHU Timone, AP-HM, France

Diffusion imaging has been widely used since the beginning of the 2000s in the study of human partial epilepsies. However, despite the numerous published works conducted during ictal as well as interictal period, the exact interpretation of these data and their potential use in clinical practice are not clearly established. In this paper, we reviewed the literature in animals and Human (including our personal works funded by a LFCE-GlaxoSmithKline fellowship), in order to support our current hypothesis concerning the significance of diffusion abnormalities and their potential clinical use.