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Treating acute seizures with benzodiazepines: does seizure duration matter? Volume 16, special issue 1, October 2014

  • [Alldredge et al., 1995] Alldredge B.K., Wall D.B., Ferriero D.M. Effect of prehospital treatment on the outcome of status epilepticus in children. Pediatr Neurol. 1995;12:213-216.
  • [Alldredge et al., 2001] Alldredge B.K., Gelb A.M., Isaacs S.M. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001;345:631-637.
  • [Amin and Weiss, 1993] Amin J., Weiss D.S. GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature. 1993;366:565-569.
  • [Bannai et al., 2009] Bannai H., Levi S., Schweizer C. Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics. Neuron. 2009;62:670-682.
  • [Berg et al., 1996] Berg A.T., Levy S.R., Novotny E.J., Shinnar S. Predictors of intractable epilepsy in childhood: a case-control study. Epilepsia. 1996;37:24-30.
  • [Ben-Ari, 1985] Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience. 1985;14:375-403.
  • [Benke et al., 1994] Benke D., Fritschy J.M., Trzeciak A., Bannwarth W., Mohler H. Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant. J Biol Chem. 1994;269:27100-27107.
  • [Bertram and Lothman, 1990] Bertram E.H., Lothman E.W. NMDA receptor antagonists and limbic status epilepticus: a comparison with standard anticonvulsants. Epilepsy Res. 1990;5:177-184.
  • [Bianchi and Macdonald, 2002] Bianchi M.T., Macdonald R.L. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. J Physiol. 2002;544:3-18.
  • [Borris et al., 2000] Borris D.J., Bertram E.H., Kapur J. Ketamine controls prolonged status epilepticus. Epilepsy Res. 2000;42:117-122.
  • [Bouthour et al., 2012] Bouthour W., Leroy F., Emmanuelli C. A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors. Cereb Cortex. 2012;22:1542-1553.
  • [Brickley et al., 1996] Brickley S.G., Cull-Candy S.G., Farrant M. Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. J Physiol. 1996;497:753-759.
  • [Brooks-Kayal, 2005] Brooks-Kayal A.R. Rearranging receptors. Epilepsia. 2005;46:29-38.
  • [Brooks-Kayal et al., 1998] Brooks-Kayal A.R., Shumate M.D., Jin H., Rikhter T.Y., Coulter D.A. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med. 1998;4:1166-1172.
  • [Brophy et al., 2012] Brophy G.M., Bell R., Claassen J. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012;17:3-23.
  • [Brown et al., 2002] Brown N., Kerby J., Bonnert T.P., Whiting P.J., Wafford K.A. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. Br J Pharmacol. 2002;136:965-974.
  • [Cavalheiro et al., 1991] Cavalheiro E.A., Leite J.P., Bortolotto Z.A., Turski W.A., Ikonomidou C., Turski L. Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia. 1991;32:778-782.
  • [Cavalheiro et al., 1996] Cavalheiro E.A., Santos N.F., Priel M.R. The pilocarpine model of epilepsy in mice. Epilepsia. 1996;37:1015-1019.
  • [Claassen et al., 2002] Claassen J., Lokin J.K., Fitzsimmons B.F., Mendelsohn F.A., Mayer S.A. Predictors of functional disability and mortality after status epilepticus. Neurology. 2002;58:139-142.
  • [de Borchgrave et al., 2003] de Borchgrave V., Lienard F., Willemart T., van Rijckevorsel K. Clinical and EEG findings in six patients with altered mental status receiving tiagabine therapy. Epilepsy Behav. 2003;4:326-337.
  • [DeLorenzo et al., 1996] DeLorenzo R.J., Hauser W.A., Towne A.R. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology. 1996;46:1029-1035.
  • [Deshpande et al., 2008] Deshpande L.S., Lou J.K., Mian A. Time course and mechanism of hippocampal neuronal death in an model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol. 2008;583:73-83. in vitro
  • [Dreifuss et al., 1998] Dreifuss F.E., Rosman N.P., Cloyd J.C. A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med. 1998;338:1869-1875.
  • [Dube et al., 2009] Dube C.M., Zhou J.L., Hamamura M. Cognitive dysfunction after experimental febrile seizures. Exp Neurol. 2009;215:167-177.
  • [Dube et al., 2010] Dube C.M., Ravizza T., Hamamura M. Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci. 2010;30:7484-7494.
  • [Dunn, 1988] Dunn D.W. Status epilepticus in children: etiology, clinical features, and outcome. J Child Neurol. 1988;3:167-173.
  • [Essrich et al., 1998] Essrich C., Lorez M., Benson J.A., Fritschy J.M., Luscher B. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nat Neurosci. 1998;1:563-571.
  • [Fariello et al., 1989] Fariello R.G., Golden G.T., Smith G.G., Reyes P.F. Potentiation of kainic acid epileptogenicity and sparing from neuronal damage by an NMDA receptor antagonist. Epilepsy Res. 1989;3:206-213.
  • [Feng et al., 2008] Feng H.J., Mathews G.C., Kao C., Macdonald R.L. Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus. J Neurophysiol. 2008;99:1285-1293.
  • [Fitzek et al., 2001] Fitzek S., Hegemann S., Sauner D., Bonsch D., Fitzek C. Drug-induced nonconvulsive status epilepticus with low dose of tiagabine. Epileptic Disord. 2001;3:147-150.
  • [Fountain and Lothman, 1995] Fountain N.B., Lothman E.W. Pathophysiology of status epilepticus. J Clin Neurophysiol. 1995;12:326-342.
  • [Frasca et al., 2011] Frasca A., Aalbers M., Frigerio F. Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity. Neurobiol Dis. 2011;43:507-515.
  • [Fujikawa, 1995] Fujikawa D.G. Neuroprotective effect of ketamine administered after status epilepticus onset. Epilepsia. 1995;36:186-195.
  • [Gao and Greenfield, 2005] Gao L., Greenfield L.J. Activation of protein kinase C reduces benzodiazepine potency at GABAA receptors in NT2-N neurons. Neuropharmacology. 2005;48:333-342.
  • [Gaspard et al., 2013] Gaspard N., Foreman B., Judd L.M. Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. Epilepsia. 2013;54:1498-1503.
  • [Glykys and Mody, 2007] Glykys J., Mody I. The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J Physiol. 2007;582:1163-1178.
  • [Goodkin et al., 2005] Goodkin H.P., Yeh J.L., Kapur J. Status epilepticus increases the intracellular accumulation of GABAA receptors. J Neurosci. 2005;25:5511-5520.
  • [Goodkin et al., 2008] Goodkin H.P., Joshi S., Mtchedlishvili Z., Brar J., Kapur J. Subunit-specific trafficking of GABA(A) receptors during status epilepticus. J Neurosci. 2008;28:2527-2538.
  • [Haas and Macdonald, 1999] Haas K.F., Macdonald R.L. GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts. J Physiol. 1999;514:27-45.
  • [Hesdorffer et al., 2011] Hesdorffer D.C., Benn E.K., Bagiella E. Distribution of febrile seizure duration and associations with development. Ann Neurol. 2011;70:93-100.
  • [Holtkamp et al., 2005] Holtkamp M., Matzen J., van Landeghem F., Buchheim K., Meierkord H. Transient loss of inhibition precedes spontaneous seizures after experimental status epilepticus. Neurobiol Dis. 2005;19:162-170.
  • [Hu and Quick, 2008] Hu J., Quick M.W. Substrate-mediated regulation of gamma-aminobutyric acid transporter 1 in rat brain. Neuropharmacology. 2008;54:309-318.
  • [Jacob et al., 2008] Jacob T.C., Moss S.J., Jurd R. GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci. 2008;9:331-343.
  • [Jensen et al., 2003] Jensen K., Chiu C.S., Sokolova I., Lester H.A., Mody I. GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. J Neurophysiol. 2003;90:2690-2701.
  • [Jones et al., 2002] Jones D.M., Esmaeil N., Maren S., Macdonald R.L. Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. Epilepsy Res. 2002;50:301-312.
  • [Joshi and Kapur, 2013] Joshi S., Kapur J. N-methyl-D-aspartic acid receptor activation downregulates expression of delta subunit-containing GABAA receptors in cultured hippocampal neurons. Mol Pharmacol. 2013;84:1-11.
  • [Kapur and Lothman, 1989] Kapur J., Lothman E.W. Loss of inhibition precedes delayed spontaneous seizures in the hippocampus after tetanic electrical stimulation. J Neurophysiol. 1989;61:427-434.
  • [Kapur and Lothman, 1990] Kapur J., Lothman E.W. NMDA receptor activation mediates the loss of GABAergic inhibition induced by recurrent seizures. Epilepsy Res. 1990;5:103-111.
  • [Kapur and Coulter, 1995] Kapur J., Coulter D.A. Experimental status epilepticus alters gamma-aminobutyric acid type A receptor function in CA1 pyramidal neurons. Ann Neurol. 1995;38:893-900.
  • [Kapur and Macdonald, 1997] Kapur J., Macdonald R.L. Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors. J Neurosci. 1997;17:7532-7540.
  • [Kapur and Macdonald, 1999] Kapur J., Macdonald R.L. Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA receptor pharmacological properties. Mol Pharmacol. 1999;55:444-452.
  • [Kapur et al., 1989] Kapur J., Stringer J.L., Lothman E.W. Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition. J Neurophysiol. 1989;61:417-426.
  • [Knoflach et al., 1996] Knoflach F., Benke D., Wang Y. Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol Pharmacol. 1996;50:1253-1261.
  • [Knudsen, 1979] Knudsen F.U. Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children. Arch Dis Child. 1979;54:855-857.
  • [Kutlu et al., 2003] Kutlu N.O., Dogrul M., Yakinci C., Soylu H. Buccal midazolam for treatment of prolonged seizures in children. Brain Dev. 2003;25:275-278.
  • [Lee et al., 2010] Lee H.H., Jurd R., Moss S.J. Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol Cell Neurosci. 2010;45:173-179.
  • [Leppik et al., 1983] Leppik I.E., Derivan A.T., Homan R.W., Walker J., Ramsay R.E., Patrick B. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA. 1983;249:1452-1454.
  • [Lowenstein, 1999] Lowenstein DH. Status epilepticus: an overview of the clinical problem. Epilepsia 1999; 40: S3-8; discussion: S21-2.
  • [Lowenstein and Alldredge, 1993] Lowenstein D.H., Alldredge B.K. Status epilepticus at an urban public hospital in the 1980s. Neurology. 1993;43:483-488.
  • [Lowenstein and Alldredge, 1998] Lowenstein D.H., Alldredge B.K. Status epilepticus. N Engl J Med. 1998;338:970-976.
  • [Lowenstein et al., 1999] Lowenstein D.H., Bleck T., Macdonald R.L. It's time to revise the definition of status epilepticus. Epilepsia. 1999;40:120-122.
  • [Mahmoudian and Zadeh, 2004] Mahmoudian T., Zadeh M.M. Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children. Epilepsy Behav. 2004;5:253-255.
  • [Mayer et al., 2002] Mayer S.A., Claassen J., Lokin J., Mendelsohn F., Dennis L.J., Fitzsimmons B.F. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol. 2002;59:205-210.
  • [Maytal et al., 1989] Maytal J., Shinnar S., Moshé S.L., Alvarez L.A. Low morbidity and mortality of status epilepticus in children. Pediatrics. 1989;83:323-331.
  • [Mazarati and Wasterlain, 1999] Mazarati A.M., Wasterlain C.G. N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat. Neurosci Lett. 1999;265:187-190.
  • [Mazarati et al., 1998a] Mazarati A.M., Baldwin R.A., Sankar R., Wasterlain C.G. Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus. Brain Res. 1998;814:179-185.
  • [Mazarati et al., 1998b] Mazarati A.M., Wasterlain C.G., Sankar R., Shin D. Self-sustaining status epilepticus after brief electrical stimulation of the perforant path. Brain Res. 1998;801:251-253.
  • [McIntyre et al., 2005] McIntyre J., Robertson S., Norris E. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 2005;366:205-210.
  • [Meldrum and Horton, 1973] Meldrum B.S., Horton R.W. Physiology of status epilepticus in primates. Arch Neurol. 1973;28:1-9.
  • [McKernan and Whiting, 1996] McKernan R.M., Whiting P.J. Which GABAA-receptor subtypes really occur in the brain?. Trends Neurosci. 1996;19:139-143.
  • [Morrisett et al., 1987] Morrisett R.A., Jope R.S., Snead O.C. 3rd. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Exp Neurol. 1987;97:193-200.
  • [Muir et al., 2010] Muir J., Arancibia-Carcamo I.L., MacAskill A.F., Smith K.R., Griffin L.D., Kittler J.T. NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the gamma2 subunit. PNAS. 2010;107:16679-16684.
  • [Naylor, 2010] Naylor D.E. Glutamate and GABA in the balance: convergent pathways sustain seizures during status epilepticus. Epilepsia. 2010;51:106-109.
  • [Naylor and Wasterlain, 2005] Naylor D.E., Wasterlain C.G. GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation. Epilepsia. 2005;46:142-147.
  • [Naylor et al., 2002] Naylor D.E., Liu H., Wasterlain C.G. Alterations in inhibition occur early during status epilepticus and include internalization of GABA subtype A receptors. Epilepsia. 2002;43:141. S1
  • [Naylor et al., 2005] Naylor D.E., Liu H., Wasterlain C.G. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci. 2005;25:7724-7733.
  • [Naylor et al., 2013] Naylor D.E., Liu H., Niquet J., Wasterlain C.G. Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus. Neurobiol Dis. 2013;54:225-238.
  • [Nusser et al., 1997] Nusser Z., Cull-Candy S., Farrant M. Differences in synaptic GABA(A) receptor number underlie variation in GABA mini amplitude. Neuron. 1997;19:697-709.
  • [Nusser et al., 1998] Nusser Z., Sieghart W., Somogyi P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci. 1998;18:1693-1703.
  • [Peng et al., 2004] Peng Z., Huang C.S., Stell B.M., Mody I., Houser C.R. Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy. J Neurosci. 2004;24:8629-8639.
  • [Poulter et al., 1999] Poulter M.O., Brown L.A., Tynan S., Willick G., William R., McIntyre D.C. Differential expression of alpha1, alpha2, alpha3, and alpha5 GABAA receptor subunits in seizure-prone and seizure-resistant rat models of temporal lobe epilepsy. J Neurosci. 1999;19:4654-4661.
  • [Pritchett et al., 1989] Pritchett D.B., Sontheimer H., Shivers B.D. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature. 1989;338:582-585.
  • [Rajasekaran et al., 2012] Rajasekaran K., Todorovic M., Kapur J. Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus. Ann Neurol. 2012;72:91-102.
  • [Rakhade et al., 2008] Rakhade S.N., Zhou C., Aujla P.K., Fishman R., Sucher N.J., Jensen F.E. Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures. J Neurosci. 2008;28:7979-7990.
  • [Rakhade et al., 2012] Rakhade S.N., Fitzgerald E.F., Klein P.M. Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. J Neurosci. 2012;32:17800-17812.
  • [Raol et al., 2006] Raol Y.H., Zhang G., Lund I.V., Porter B.E., Maronski M.A., Brooks-Kayal A.R. Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia. 2006;47:1665-1673.
  • [Rice and DeLorenzo, 1998] Rice A.C., DeLorenzo R.J. NMDA receptor activation during status epilepticus is required for the development of epilepsy. Brain Res. 1998;782:240-247.
  • [Rice and DeLorenzo, 1999] Rice A.C., DeLorenzo R.J. N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam. Neuroscience. 1999;93:117-123.
  • [Rivera et al., 2004] Rivera C., Voipio J., Thomas-Crusells J. Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci. 2004;24:4683-4691.
  • [Riviello et al., 2013] Riviello J.J. Jr., Claassen J., LaRoche S.M. Treatment of status epilepticus: an international survey of experts. Neurocrit Care. 2013;18:193-200.
  • [Rosati et al., 2012] Rosati A., L’Erario M., Ilvento L. Efficacy and safety of ketamine in refractory status epilepticus in children. Neurology. 2012;79:2355-2358.
  • [Rossetti et al., 2002] Rossetti A.O., Milligan T.A., Vulliemoz S., Michaelides C., Bertschi M., Lee J.W. A randomized trial for the treatment of refractory status epilepticus. Neurocrit Care. 2002;14:4-10.
  • [Sanchez et al., 2005] Sanchez R.M., Dai W., Levada R.E., Lippman J.J., Jensen F.E. AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain. J Neurosci. 2005;25:3442-3451.
  • [Sankar et al., 1997] Sankar R., Shin D.H., Wasterlain C.G. Serum neuron-specific enolase is a marker for neuronal damage following status epilepticus in the rat. Epilepsy Res. 1997;28:129-136.
  • [Saxena and Macdonald, 1996] Saxena N.C., Macdonald R.L. Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms. Mol Pharmacol. 1996;49:567-579.
  • [Schwagmeier et al., 1998] Schwagmeier R., Alincic S., Striebel H.W. Midazolam pharmacokinetics following intravenous and buccal administration. Br J Clin Pharmacol. 1998;46:203-206.
  • [Scott, 2005] Scott R.C. Buccal midazolam as rescue therapy for acute seizures. Lancet Neurol. 2005;4:592-593.
  • [Scott et al., 1999] Scott R.C., Besag F.M., Neville B.G. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet. 1999;353:623-626.
  • [Serafini et al., 2000] Serafini R., Bracamontes J., Steinbach J.H. Structural domains of the human GABAA receptor 3 subunit involved in the actions of pentobarbital. J Physiol. 2000;524:649-676.
  • [Shinnar et al., 2001] Shinnar S., Berg A.T., Treiman D.M. Status epilepticus and tiagabine therapy: review of safety data and epidemiologic comparisons. Epilepsia. 2001;42:372-379.
  • [Shinnar et al., 2008] Shinnar S., Hesdorffer D.C., Nordli D.R. Jr. Phenomenology of prolonged febrile seizures: results of the FEBSTAT study. Neurology. 2008;71:170-176.
  • [Shorvon, 2011] Shorvon S. Super-refractory status epilepticus: an approach to therapy in this difficult clinical situation. Epilepsia. 2011;52:53-56.
  • [Sigel et al., 1990] Sigel E., Baur R., Trube G., Mohler H., Malherbe P. The effect of subunit composition of rat brain GABAA receptors on channel function. Neuron. 1990;5:703-711.
  • [Silbergleit et al., 2012] Silbergleit R., Durkalski V., Lowenstein D. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366:591-600.
  • [Staley, 1992] Staley K. Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines. Neurosci Lett. 1992;146:105-107.
  • [Synowiec et al., 2013] Synowiec A.S., Singh D.S., Yenugadhati V., Valeriano J.P., Schramke C.J., Kelly K.M. Ketamine use in the treatment of refractory status epilepticus. Epilepsy Res. 2013;105:183-188.
  • [Terunuma et al., 2008] Terunuma M., Xu J., Vithlani M. Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci. 2008;28:376-384.
  • [Towne et al., 1994] Towne A.R., Pellock J.M., Ko D., DeLorenzo R.J. Determinants of mortality in status epilepticus. Epilepsia. 1994;35:27-34.
  • [Treiman et al., 1998] Treiman D.M., Meyers P.D., Walton N.Y. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med. 1998;339:792-798.
  • [Venkatachalan and Czajkowski, 2012] Venkatachalan S.P., Czajkowski C. Structural link between gamma-aminobutyric acid type A (GABAA) receptor agonist binding site and inner beta-sheet governs channel activation and allosteric drug modulation. J Biol Chem. 2012;287:6714-6724.
  • [Wafford et al., 1996] Wafford K.A., Thompson S.A., Thomas D., Sikela J., Wilcox A.S., Whiting P.J. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol. 1996;50:670-678.
  • [Walker, 1998] Walker M.C. The epidemiology and management of status epilepticus. Curr Opin Neurol. 1998;11:149-154.
  • [Walton and Treiman, 1988] Walton N.Y., Treiman D.M. Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. Exp Neurol. 1988;101:267-275.
  • [Walton and Treiman, 1991] Walton N.Y., Treiman D.M. Motor and electroencephalographic response of refractory experimental status epilepticus in rats to treatment with MK-801, diazepam, or MK-801 plus diazepam. Brain Res. 1991;553:97-104.
  • [Walton et al., 1990] Walton N.Y., Gunawan S., Treiman D.M. Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine. Exp Neurol. 1990;108:61-70.
  • [Walton et al., 1994] Walton N.Y., Gunawan S., Treiman D.M. Treatment of experimental status epilepticus with the GABA uptake inhibitor, tiagabine. Epilepsy Res. 1994;19:237-244.
  • [Wang et al., 2003] Wang J., Liu S., Haditsch U. Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J Neurosci. 2003;23:826-836.
  • [Wasterlain et al., 1993] Wasterlain C.G., Baxter C.F., Baldwin R.A. GABA metabolism in the substantia nigra, cortex, and hippocampus during status epilepticus. Neurochem Res. 1993;18:527-532.
  • [Wei et al., 2003] Wei W., Zhang N., Peng Z., Houser C.R., Mody I. Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J Neurosci. 2003;23:10650-10661.
  • [Working Group on Status Epilepticus, 1993] Working group on Status Epilepticus. Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America?s Working group on Status Epilepticus. JAMA. 1993;270:851-859.
  • [Wu et al., 2007] Wu Y., Wang W., Diez-Sampedro A., Richerson G.B. Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1. Neuron. 2007;56:851-865.
  • [Zhang et al., 2004] Zhang G., Raol Y.H., Hsu F.C., Coulter D.A., Brooks-Kayal A.R. Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience. 2004;125:299-303.