John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

Temporal lobe neoplasm and seizures: how deep does the story go? Volume 10, issue 1, march 2008


  • Temporal lobe neoplasm and seizures: how deep does the story go?


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Epilepsy Center, Cleveland Clinic Foundation, Epilepsy Center, University Hospitals, Cleveland, Department of Neurology, University of Vermont College of Medicine, Burlington, VA, Department of Pathology, Cleveland Clinic Foundation, Ohio, USA
  • Key words: temporal lobe epilepsy, neoplasm, cortical dysplasia
  • DOI : 10.1684/epd.2008.0173
  • Page(s) : 56-67
  • Published in: 2008

[March 2008 - Cleveland Case Report]. There is a well-described association between the occurrence of developmental tumors and the presence of cortical dysplasia in the neighboring brain tissue. The main surgical approaches in the treatment of medically refractory epilepsy related to such developmental tumors include a lesionectomy versus a tailored cortical resection, often guided by an invasive evaluation. This case report describes the surgical management of a 26-year-old female with olfactory auras evolving into automotor seizures and convulsions, occurring in the context of a right temporo-parietal developmental lesion. It illustrates the pros and cons of various surgical approaches, and discusses some pathophysiological aspects of developmental tumors, dysplasia and epilepsy. [Published with video sequences]