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Sultiame revisited: treatment of refractory absence seizures Volume 18, issue 3, September 2016

TEST YOURSELF

(1) What are the clinical and EEG features which distinguish between typical and atypical absence seizures?

 

(2) What types of seizures and/or epilepsy syndromes should treatment with sultiame be considered for?

 

(3) What are the potential side effects of sultiame?

 

 

 

 

 

 

 

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Answers

(1) Typical absence seizures: 3-Hz spike-wave discharge, brief (seconds), usually with normal intellect, and usually no other neurological abnormalities. Atypical absences: usually within the setting of learning disabilities, of usually longer duration, with more complex clinical features, and a more irregular and shorter frequency of spiking (usually less than 3 Hz).


(2) Idiopathic focal epilepsies and related epileptic encephalopathies (BFEC, ESES, LKS, etc). Efficacy in controlling typical, drug resistant, absence seizures in genetically determined generalized epilepsies is also reported and further studies should be considered.


(3) Hyperpnoea, paraesthesia, cognitive impairment, anorexia, nausea, and dizziness.

 

 

 

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