John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

Refractory chronic epilepsy associated with neuronal auto-antibodies: could perisylvian semiology be a clue? Volume 19, issue 4, December 2017


  • Figure 1


1 Mater Advanced Epilepsy Unit, Mater Adults Hospital,
2 Princess Alexandra Hospital, Department of Neurology, Brisbane, Australia
* Correspondence: Sasha Dionisio Advanced Epilepsy Unit, Centre for neurosciences, Mater Adults Hospital, South Brisbane, 4101 Qld, Australia
  • Key words: autoimmune epilepsy, perisylvian semiology, insula, anti-glycine antibody, GAD-65 antibody
  • DOI : 10.1684/epd.2017.0946
  • Page(s) : 439-49
  • Published in: 2017


We report a case series of 10 patients with chronic medically refractory antibody-positive autoimmune epilepsy and assess their common clinical features. Immune-mediated seizures are most commonly reported in the context of encephalitis or encephalopathy, with few reports focusing on lone, chronic epilepsy in the outpatient setting. Our aim was to define the potential diagnostic clues that might be present in these cases, leading to consideration of an autoimmune cause of the epilepsy.