John Libbey Eurotext

Pronounced microcephaly in a patient with malignant migrating partial seizures in infancy Volume 9, issue 1, March 2007

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  • Pronounced microcephaly in a patient with malignant migrating partial seizures in infancy

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Authors
Department of Neuropediatrics, University of Giessen, Germany

Malignant migrating partial seizures in infancy is an age-specific epilepsy syndrome, resistant to conventional antiepileptic drugs in most cases. Since the first description of 14 infants in 1995, only 16 additional patients have been reported. We add a further case and present a video that shows a typical generalizing tonic seizure arising from the right temporo-occipital area and slowly spreading about both hemispheres. In addition to other symptoms previously described, almost complete arrest of brain growth with onset of seizures and evolution of distinctive secondary microcephaly were striking features in this patient. [Published with video sequences]