Figure 2.
(A) SEEG recording showing electroclinical correlation during a typical seizure in Patient 2, time-locked to specific grimacing evolving to laughing gelastic automatism. (B) 3D representation showing brain connectivity estimated using non-linear regression analysis based on h2 coefficient during grimacing clinical manifestation with respect to the ictal onset interval. Increased/decreased connectivity is highlighted in red/blue colour, respectively (the strength of connectivity is proportional to the thickness of the lines). The main brain structures in the network showing significant h2 coefficients are the posterior cingulate cortex, fusiform gyrus, amygdala, orbitofrontal cortex, and dorsal-lateral prefrontal cortex. (C) Time-frequency maps highlighting gamma band activity at seizure onset at contacts V07-08 and I01-02, corresponding to the intraparietal sulcus, inferior parietal lobule and temporal pole;electrical seizure onset is marked by an asterisk. (D) Gamma activity at 30-80 Hz related to grimacing, superimposed on MRI.