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Epileptic Disorders

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Motor and emotional facial features in parietal lobe seizures: an ictal functional connectivity study using SEEG Volume 24, issue 5, October 2022

Figure 1.

(A) SEEG recording of electroclinical onset and evolution of a typical seizure in Patient 1 showing an ictal pouting grimace time-locked with low-voltage fast activity over the electrodes sampling the inferior parietal lobule. (B) 3D representation showing brain connectivity estimated using non-linear regression analysis based on h2 coefficient during clinical manifestation of grimacing with respect to the ictal onset interval. Increased/decreased connectivity is highlighted in red/blue colour, respectively (the strength of connectivity is proportional to the thickness of the lines). The main brain structures in the network showing significant h2 coefficients are the inferior parietal lobule, anterior insular cortex, frontal operculum and dorsal-lateral prefrontal cortex. (D) Time-frequency maps highlighting gamma band activity at seizure onset at contacts V12-13 and F08-09 corresponding to the inferior parietal lobule and posterior temporal neocortical region;electrical seizure onset is marked by an asterisk. (C) Gamma activity at 30-80 Hz related to grimacing, superimposed on MRI.

Figure 2.

(A) SEEG recording showing electroclinical correlation during a typical seizure in Patient 2, time-locked to specific grimacing evolving to laughing gelastic automatism. (B) 3D representation showing brain connectivity estimated using non-linear regression analysis based on h2 coefficient during grimacing clinical manifestation with respect to the ictal onset interval. Increased/decreased connectivity is highlighted in red/blue colour, respectively (the strength of connectivity is proportional to the thickness of the lines). The main brain structures in the network showing significant h2 coefficients are the posterior cingulate cortex, fusiform gyrus, amygdala, orbitofrontal cortex, and dorsal-lateral prefrontal cortex. (C) Time-frequency maps highlighting gamma band activity at seizure onset at contacts V07-08 and I01-02, corresponding to the intraparietal sulcus, inferior parietal lobule and temporal pole;electrical seizure onset is marked by an asterisk. (D) Gamma activity at 30-80 Hz related to grimacing, superimposed on MRI.