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LGI-1 antibody encephalitis in a seven-year-old girl Volume 21, issue 6, December 2019

TEST YOURSELF

(1) LGI-1 limbic encephalitis can be seen in: 

A. Adults  

B. Children  

C. Both adults and children 

D. None of the above 

 

(2) LGI-1 limbic encephalitis can present with which of the following seizure types? 

A. Faciobrachial dystonic seizures 

B. Focal seizures with automatisms 

C. Generalized tonic-clonic seizures 

D. All of the above 

 

(3) What is the first-line treatment for LGI-1 limbic encephalitis presenting with very frequent seizures? 

A. Antiepileptic drugs 

B. Pharmacological coma 

C. Combination of IVIG and steroids 

D. IVIG 

 

 

 

 

 

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Answers

(1) C. LGI-1 limbic encephalitis can be seen in both adults and children. A high index of suspicion is also needed in children to appropriately diagnose and treat this condition.

 

(2) D. Patients with LGI-1 limbic encephalitis can present with multiple seizure types including characteristic FBDS, focal seizures with automatisms, generalized tonic-clonic seizures, drop attacks, and myoclonic seizures.

 

(3) C. Antiepileptic drugs alone usually are not helpful. First-line treatment includes glucocorticoids and IVIG, and combination of the two has been shown to be better. Patients show an excellent response to immunotherapy.

 

 

 

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