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Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations Volume 11, issue 4, December 2009

Figure 1 Ictal EEG before pyridoxine treatment (patient 1) during unresponsiveness, eye fluttering and eye deviation showing: (1) left-sided semi-rhythmic sharp and slow wave activity, and (2) concurrent right temporal periodic discharges with beta discharges followed by semi-rhythmic sharp and slow waves.

Figure 2 EEGs after pyridoxine treatment (patient 1). A) Two days post-pyridoxine treatment showing presence of burst suppression mainly on the right with some ongoing left semi-rhythmic delta activity. B) Three days post-pyridoxine treatment showing presence of burst suppression on the right for one minute during a 30-minute EEG, the rest of the EEG being as in C.

Figure 2 (continued) EEGs after pyridoxine treatment (patient 1). C) Five days post-pyridoxine treatment showing diffuse slowing of the background with occasional sharp waves and some spindle activity. D) 22 days post-pyridoxine treatment showing transient worsening (as compared to day five in C): asymmetric background with more slowing and higher amplitude over the right side in wakefulness and in sleep, with very frequent discharges which were predominantly right-sided with superimposed very frequent spikes and spike wave discharges.