JLE

Epileptic Disorders

MENU

Electroclinical history of a five-year-old girl with GRIN1-related early-onset epileptic encephalopathy: a video-case study Volume 20, issue 5, October 2018

(A) EEG recorded at the age of one month and 22 days during sleep shows diffuse and continuous slow, low-medium-voltage activity with recurrent superimposed theta sharp waves and spindlelike sequences on right fronto-central regions. (B) Oculogyric movements, sucking automatisms, and choreoathetoid and stereotyped movements of the four limbs while awake, concomitant with posterior medium-voltage, 4-5-Hz activity with no epileptiform discharges (at two years and five months). (C) Persistence of oculogyric, choreoathetoid, and stereotyped movements, associated with diffuse background slowing and artefacts, with no clear epileptiform discharges. (D) Oculomotor movements, resembling oculogyric crises (right upward eye deviation, converging movements, blinking with pupil dilation, and some opsoclonic jerks), mostly induced by visual fixation, are associated with high-voltage, bi-triphasic spikes and polyspikes on right centro-temporal-occipital regions (at five years and four months).

> Download