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Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy Volume 24, issue 3, June 2022

  • [1.] World Health Organization. Epilepsy. WHO. 2019. www.who.int/news-room/fact-sheets/detail/epilepsy
  • [2.] Thomas SV, Ajaykumar B, Sindhu K, Nair MK, George B, Sarma PS. Motor and mental development of infants exposed to antiepileptic drugs in utero. Epilepsy Behav 2008; 13(1): 229-36.
  • [3.] Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, et al. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med 2009;360(16): 1597-605.
  • [4.] Thomas SV, Sukumaran S, Lukose N, George A, Sarma PS. Intellectual and language functions in children of mothers with epilepsy. Epilepsia 2007;48(12): 2234-40.
  • [5.] Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J, et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol 2013;12(3): 244-52.
  • [6.] Bromley RL, Mawer GE, Briggs M, Cheyne C, Clayton-Smith J, Garcfa-Finana M, et al. The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013;84 (6): 637-43.
  • [7.] Unnikrishnan G, Jacob NS, Salim S, Jose M, Salini RA, Pavithran V, et al. Enduring language deficits in children of women with epilepsy and the potential role of intrauterine exposure to antiepileptic drugs. Epilepsia 2020;61(11): 2442-51.
  • [8.] Gopinath N, Muneer AK, Unnikrishnan S, Varma RP, Thomas SV. Children (10-12 years age) of women with epilepsy have lower intelligence, attention and memory: observations from a prospective cohort case control study. Epilepsy Res 2015;117: 58-62.
  • [9.] Lake A. Early childhood development global action is overdue. Lancet 2011;378(9799): 1277-8.
  • [10.] Saramma PP, Thomas SV, Sarma PS. Child rearing issues for mothers with epilepsy: a case control study. Ann Indian Acad Neurol 2006;9(3): 158.
  • [11.] CDC. Why act early if you're concerned about development? Centers for Disease Control and Prevention. 2021. www.cdc.gov/ncbddd/actearly/whyActEarly.html
  • [12.] Thomas SV, Indrani L, Devi GC, Jacob S, Beegum J, Jacob PP, et al. Pregnancy in women with epilepsy: preliminary results of Kerala registry of epilepsy and pregnancy. Neurol India 2001;49(1): 60-6.
  • [13.] Thomas SV, Jose M, Divakaran S, Sankara Sarma P. Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: results from a pregnancy registry in South India. Epilepsia 2017;58(2): 274-81.
  • [14.] Phatak P. Mental and motor growth of Indian babies (1 month-30 months). (Longitudinal growth of Indian children). Final Report. 1970.
  • [15.] Nair MKC, Krishnan R, Harikumaran Nair GS, Bhaskaran D, Leena ML, George B, et al. CDC Kerala 4: TDSC items based developmental therapy package among low birth weight babies outcome at 18 months using DASII. Indian J Pediatr 2014;81(Suppl 2): S85-90.
  • [16.] Meador KJ, Cohen MJ, Loring DW, May RC, Brown C, Robalino CP, et al. Two-year-old cognitive outcomes in children of pregnant women with epilepsy in the maternal
  • [17.] Scolnik D, Nulman I, Rovet J, Gladstone D, Czuchta D, Gardner HA, et al. Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. JAMA 1994; 271(10): 767-70.
  • [18.] Gaily E, Kantola-Sorsa E, Hiilesmaa V, Isoaho M, Matila R, Kotila M, et al. Normal intelligence in children with prenatal exposure to carbamazepine. Neurology 2004; 62(1): 28-32.
  • [19.] Ornoy A, Cohen E. Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. Arch Dis Child 1996; 75(6): 517-20.
  • [20.] Matlow J, Koren G. Is carbamazepine safe to take during pregnancy? Can Fam Physician 2012; 58(2): 163-4.
  • [21.] Banach R, Boskovic R, Einarson T, Koren G. Long-term developmental outcome of children of women with epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies. Drug Saf 2010; 33(1): 73-9.
  • [22.] Blotière PO, Miranda S, Weill A, Mikaeloff Y, Peyre H, Ramus F, et al. Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. BMJ Open 2020; 10(6): e034829.
  • [23.] Veroniki AA, Rios P, Cogo E, Straus SE, Finkelstein Y, Kealey R, et al. Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis. BMJ Open 2017; 7(7): e017248.
  • [24.] Almgren M, Källén B, Lavebratt C. Population-based study of antiepileptic drug exposure in utero influence on head circumference in newborns. Seizure 2009; 18(10): 672-5.
  • [25.] Sreedharan RM, Sheelakumari R, Anila KM, Kesavadas C, Thomas SV. Reduced brain volumes in children of women with epilepsy: a neuropsychological and voxel based morphometric analysis in pre-adolescent children. J Neuroradiol 2018; 45(6): 380-5.
  • [26.] Sreedharan RM, Kesavadas C, Aiyappan S, Anila KM, Mohan AC, Thomas SV. Functional language network connectivity in children of women with epilepsy with selective antenatal antiepileptic drug exposure. Ann Indian Acad Neurol 2020; 23(2): 167.
  • [27.] Wood AG, Chen J, Barton S, Nadebaum C, Anderson VA, Catroppa C, et al. Altered cortical thickness following prenatal sodium valproate exposure. Ann Clin Transl Neurol 2014; 1(7): 497-501.
  • [28.] Manthou ME, Meditskou S, Lykartsis C, Sapalidis K, Sorkou K, Emmanouil-Nikoloussi E-N. The role of neuronal apoptosis in Valproic Acid brain-related teratogenesis: a histochemical and immunohistochemical study in BALB/c mice. Rom J Morphol Embryol 2020; 61(3): 813-9.
  • [29.] Kaushal S, Tamer Z, Opoku F, Forcelli PA. Anticonvulsant drug induced cell death in the developing white matter of the rodent brain. Epilepsia 2016; 57(5): 727-34.