Epileptic Disorders


Coregistration of multimodal imaging is associated with favourable two-year seizure outcome after paediatric epilepsy surgery Volume 19, issue 1, March 2017


(1) Multimodal imaging coregistration may impact surgical evaluations and treatment of intractable epilepsy in multiple ways. Name some examples.


(2) In patients evaluated with multimodal coregistered imaging, we noted improved outcome at two years post-operation. Was this type of imaging analysis more useful in patients with temporal or extratemporal procedures?



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(1) In this manuscript, multimodal coregistered imaging was associated with improved seizure reduction at one and two years following epilepsy surgery and with fewer two-stage epilepsy surgeries. Other authors have demonstrated the use of multimodal imaging coregistration results in fewer two-stage surgeries (Salamon, et al., 2008), fewer electrodes implanted and smaller craniotomies (Seo et al., 2011), and changes in surgical planning and electrode placement (Nowell et al., 2015).

(2) Patients undergoing extratemporal lobe procedures (59% vs. 25%; χ2[1]=12.18; p<0.001) and temporal lobe procedures (69% vs. 38%; χ2[1]=8.67; p=0.003) experienced improvement in postoperative seizure freedom following the institution of coregistration imaging protocols


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