JLE

Epileptic Disorders

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Changes in white matter microstructure in patients with TLE and hippocampal sclerosis Volume 11, issue 3, September 2009

Figure 1 Map of the main FA decrease in patients with HS-TLE compared to healthy, age- and sex-matched controls. Volume maps of FA decline with disease computed by voxel level t-tests between the patients and the controls. Significant decline of FA (p < 0,05) was displayed in red/yellow. The colour scale at the bottom represents the significance of the FA change with yellow indicating regions of most significant decline. A) Sagittal view of the left temporal lobe showing decreased FA in the temporal lobe white matter. B, C) Coronal views showing the reduced FA bitemporally, in the left frontal region and in the corpus callosum. D) Axial view showing reduced FA in the temporal white matter.

Figure 2 Regional differences in FA in the hippocampus of patients with left HS-TLE compared to healthy controls: The FA measured in the affected hippocampus was significantly reduced compared to the healthy side.

Figure 3 Regional FA values in patients with left temporal epilepsy due to hippocampal sclerosis and in healthy controls.* Significance; ACC: anterior corpus callosum; MCC: middle corpus callosum; PCC: posterior corpus callosum; SFG: superior frontal gyrus; FWM: frontal white matter; IFG: inferior frontal gyrus; TWM: temporal lobe white matter; PG: parahippocampal gyrus; r: right; l: left.