Université Clermont-Auvergne, Clermont-Ferrand,
Aix Marseille Univ, Institut de Neurosciences des Systèmes, Marseille,
AP-HM, Hôpital de la Timone, Service d’Epileptologie, Marseille, France
Correspondence: Fabrice Bartolomei
Service d’épileptologie et rythmologie cérébrale,
264 Rue St Pierre 13005,
Coughing is a reflex phenomenon that is protective for the upper airways, involving both a reflex arc in the brainstem and cortical control. Ictal coughing has been prominently reported in temporal lobe seizures, but precise anatomo-electrical correlations are lacking. We report a patient who presented with persistent coughing at seizure onset. We studied intracerebrally recorded seizures (using stereo-electroencephalography) in order to describe the anatomo-functional correlations associated with this sign. Coughing followed seizure onset in the medial temporal lobe. A functional connectivity study (h2 estimation of interdependencies) showed that during coughing, a network of cortical and subcortical regions was involved, particularly the perisylvian cortices and the caudate nucleus.