John Libbey Eurotext

European Journal of Dermatology


TS-1 (tegafur/gimeracil/oteracil)-induced systemic lupus erythematosus with skin lesions and anti-Sm antibody Volume 27, issue 6, November-December 2017


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1 Department of Dermatology,
2 Department of Surgery, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara 634-8522, Japan

Drug-induced lupus (DIL) is a rare lupus-like adverse drug reaction that regresses after discontinuation of the causative drug [1, 2]. We report a patient with DIL caused by TS-1 (tegafur, gimeracil, and oteracil, a 5-fluorouracil (5-FU) agent), who developed lupus-like skin lesions and anti-Sm antibody (Ab). The skin lesions reappeared upon rechallenge with TS-1, and drug discontinuation resulted in the prompt resolution of the skin lesions and a reduction of anti-Sm Ab titres.A 78-year-old man [...]