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SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations Volume 32, issue 1, January-February 2022

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Authors
1 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
2 Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
3 Department of Medical Surgical and Health Sciences, University of Trieste, Trieste, Italy
4 Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
5 Division of Laboratory Medicine, University Hospital Giuliano Isontina (ASU GI), Trieste, Italy
6 Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, University of Qatar, Doha, Qatar
a These authors contributed equally
b These authors contributed equally

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported [1], however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated [2]. Angiotensin-converting enzyme 2 (ACE2) is highly expressed in keratinocytes, suggesting percutaneous transmission as a potential route for SARS-CoV-2 infection [3]. Currently, the susceptibility of keratinocytes to SARS-CoV-2 has not been investigated. Thus, two HaCaT spontaneously [...]