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European Journal of Dermatology

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Refractory metastasis of cutaneous angiosarcoma showing complete response to pazopanib Volume 25, issue 1, January-February 2015

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  • Figure 1
Authors
1 Division of Dermatology,
Department of Internal Related, Kobe University Graduate School of Medicine,
7-5-1 Kusunoki-cho,
Chuo-ku, Kobe 650-0017,
Japan
2 Department of clinical Laboratory,
Kobe University Hospital,
7-5-2 Kusunoki-cho,
Chuo-ku, Kobe 650-0017,
Japan

Cutaneous angiosarcoma is an aggressive neoplasm that frequently metastasizes to the lungs, a characteristic closely associated with high mortality [1]. Although several chemotherapeutic regimens have been tried, lung metastasis is uncontrollable in almost all cases [2]. We present a case of cutaneous angiosarcoma in which the pulmonary metastasis showed a complete response (CR) to pazopanib treatment. The tumor had a mutation in the transmembrane domain of KIT.A 77-year-old man presented with a [...]