John Libbey Eurotext

European Journal of Dermatology


Pruritic eosinophilic papular eruption revealing HIV infection Volume 12, issue 6, November - December 2002


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Department of Immunodermatology, Istituto Dermopatico dell'Immacolata, IDI, IRCCS, Via Monti di Creta 104, 00167 Rome, Italy.
  • Key words: eosinophilic folliculitis, pruritic papular eruption, HIV infection, Th2-immune response.
  • Page(s) : 600-2
  • Published in: 2002

Eosinophilic folliculitis (EF) is a rare follicular pruritic papular eruption observed in association with human immunodeficiency virus (HIV). The diagnosis of eosinophilic folliculitis is based on the histologic findings consisting of a sterile inflammatory infiltrate rich in eosinophils involving hair follicles. EF in HIV patients is believed to be an immunoinflammatory response directed either at follicular or skin flora antigens in the late-stage of HIV infection. In this stage, immune response is characterized by a shift from a Th1- to a Th2-dominant cytokine profile and an increased secretion of interleukin-4 and interleukin-5, both known to promote eosinophilia. We describe a case of HIV-associated eosinophilic folliculitis in a 30-year-old black woman referred to us for a pruritic follicular eruption without any other clinical symptom related to the acquired immunodeficiency syndrome. HIV infection presenting with EF has been rarely reported and its occurrence in women is also very rare.