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European Journal of Dermatology

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Primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma with a CD15 +CD30 phenotype Volume 17, issue 5, September-October 2007

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Authors
Department of Dermatology, Shizuoka Municipal Shimizu Hospital, 1231 Miyakami Shimizu, Shizuoka 424-8636, Japan, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan

Primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma (CD8 +TCL) is an extremely rare entity with distinct clinicopathological features. While the CD15 antigen is typically associated with classic Hodgkin’s lymphoma, aggressive peripheral T-cell lymphomas, including advanced stage cutaneous T-cell lymphomas, rarely express this molecule. We report a case of primary cutaneous aggressive epidermotropic CD8 +TCL, in which lymphoma cells are CD15 +CD30 with a medium-to-large pleomorphic phenotype. Although the functional characteristics of CD15 expression in the cutaneous lymphomas are not fully understood, the poor prognosis of primary cutaneous aggressive epidermotropic CD8 +TCL might be associated with the presence of this molecule in our case.