European Journal of Dermatology
MENUPrimary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma with a CD15 +CD30 – phenotype Volume 17, issue 5, September-October 2007
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- Key words: CD8 +TCL, CD8 + T-cell lymphoma, CTCL, Cutaneous T-cell lymphoma, EBV, Epstein-Barr virus, MF, Mycosis fungoides, TCR, T-cell receptor
- DOI : 10.1684/ejd.2007.0245
- Page(s) : 441-2
- Published in: 2007
Primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma (CD8 +TCL) is an extremely rare entity with distinct clinicopathological features. While the CD15 antigen is typically associated with classic Hodgkin’s lymphoma, aggressive peripheral T-cell lymphomas, including advanced stage cutaneous T-cell lymphomas, rarely express this molecule. We report a case of primary cutaneous aggressive epidermotropic CD8 +TCL, in which lymphoma cells are CD15 +CD30 – with a medium-to-large pleomorphic phenotype. Although the functional characteristics of CD15 expression in the cutaneous lymphomas are not fully understood, the poor prognosis of primary cutaneous aggressive epidermotropic CD8 +TCL might be associated with the presence of this molecule in our case.