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European Journal of Dermatology

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Perianal Paget disease secondary to pagetoid spread of mucinous adenocarcinoma of the anal canal Volume 28, issue 2, March-April 2018

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Authors
1 Department of Dermatology and Venereology, Centro Hospitalar de Lisboa Central. Lisboa and Hospital de Santo António dos Capuchos, Department of Dermatology and Venereology, Alameda Santo António dos Capuchos, 1169-050 Lisboa, Portugal
2 Department of Pathology, Centro Hospitalar de Lisboa Central. Lisboa and Hospital de S. José, Department of Pathology, R. José António Serrano, 1150-199 Lisboa, Portugal
3 Dermatology Centre, Hospital CUF Descobertas, Lisboa and R. Mário Botas, 1998-018 Lisboa, Portugal

A 77-year-old woman with a four-month history of an asymptomatic perianal lesion was referred to our department because of “treatment-resistant perianal candidiasis”. Physical examination revealed a round, well-demarcated, erythematous plaque involving the perianal skin, with an erosive, exudative surface (figure 1A). No perianal fistulae were observed. The patient complained of anorexia and significant weight loss over the past three months.A skin biopsy was performed and histopathological examination [...]