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European Journal of Dermatology

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Paediatric spitzoid melanoma diagnosed with the aid of fluorescence in situ hybridization and mutation analysis Volume 32, issue 1, January-February 2022

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Authors
1 Department of Dermatology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan
2 Department of Pediatric surgery, Dokkyo Medical University Saitama Medical Center, Saitama, Japan
3 Department of Pathology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan
4 Department of Pathology, Saitama Medical University, International Medical Center, Saitama, Japan
5 Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, Japan

Spitz tumours are classified as Spitz nevi (SN), atypical Spitz tumours (ASTs), or Spitz melanomas, however, it is difficult to distinguish between benign and malignant lesions clinically and even pathologically [1]. Furthermore, paediatric melanomas are rare [2] and spitzoid melanomas (SM) without fusion gene mutations have been categorized differently from Spitz tumours [3]. We report a case of paediatric SM diagnosed based on fluorescence in situ hybridization (FISH) and mutation analysis.A seven-year-old [...]