European Journal of Dermatology
MENUNeutrophilic disease of the skin and intestines after ipilimumab treatment for malignant melanoma – simultaneous occurrence of pyoderma gangrenosum and colitis Volume 24, issue 2, March-April 2014
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1 Department of Dermatology,
2 1st Department of Medicine,
- DOI : 10.1684/ejd.2014.2297
- Page(s) : 268-9
- Published in: 2014
Ipilimumab is an antibody against cytotoxic T-lymphocyte antigen 4 (CTLA-4), used to treat metastatic melanoma. It induces immune-related side effects due to the immune-modifying mode of action. We present a case of neutrophilic disease with multi-organ involvement presenting as pyoderma gangrenosum (PG) and colitis developing after ipilimumab therapy.A 56-year old woman was diagnosed with malignant melanoma of the rectum in 2007. Abdominoperineal resection of the rectum with subsequent colostomy [...]