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European Journal of Dermatology

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Morphea as a sign of autoimmune syndrome induced by adjuvants (ASIA) Volume 24, issue 3, May-June 2014

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Authors
Department of Dermatology,
Hospital General Universitario de Alicante
C/Pintor Baeza s/n
03010 Alicante,
Spain

Human adjuvant disease (HAD) is a syndrome initially described by Miyoshi et al. [1]. The term encompasses a constellation of non-specific rheumatologic signs and symptoms which develop following exposure to foreign materials such as injection substances for cosmetic purposes (silicone, mineral oil, guayaco…), vaccines, environmental gases and infectious agents. These materials, generally named “adjuvants”, can trigger an aberrant immune response in predisposed individuals, characterized by a mixture [...]